Competitor Analysis: Tumor Microenvironment Modulation via IDO, TGF-B/R, CXCR4, CSF-1R, CD47-SIRPa, Adenosine, STING & Others

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Competitor Analysis: Tumor Microenvironment Modulation via IDO, TGF-B/R, CXCR4, CSF-1R, CD47-SIRPa, Adenosine, STING & Others
This Competitive Intelligence report about Tumor Microenvironment Modulation via IDO, TGF-B/R, CXCR4, CSF-1R, CD47-SIRPa, Adenosine, STING & Othersevaluates as of December 2016 the competitive field of mainly inhibitors and antagonists of substrates, enzymes and receptors involved in the immunosuppressive tumor microenvironment, including

IDO (Indoleamine 2,3-dioxygenase
TDO ( Tryptophan 2,3 dioxygenase)
TGF-B/R ( Transforming Growth Factor beta/Receptor)
CXCR4(Chemokine Receptor Type 4)
CSF-1R ( Colony Stimulating Factor-1 Receptor)
CD47 SIRPa (Signal Regulatory Protein Alpha)
Adenosine Pathway: Adenosine 2A Receptor (A2AR), CD73, CD39 & adenosine
STING (STimulator of INterferon Genes) Receptor
Others ( e.g. arginase)

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More than 45 new molecular entities modulating the immunosuppressive tumor microenvironment are in clinical development as monotherapy or in combination with other checkpoint modulators or targeted cancer therapeutics. At least further eight molecules are undergoing IND-enabling studies.
The report includes a compilation of currently active projects in research and development of modulators of the tumor microenvironment. In addition, the report lists company-specific R&D pipelines of Tumor Microenvironment Modulators. Competitor projects are listed in a tabular format providing information on:

Drug Codes,
Target / Mechanism of Action,
Class of Compound,
Company,

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Table of Content

Competitor Analysis: Tumor Microenvironment Modulation via IDO, TGF-B/R, CXCR4, CSF-1R, CD47-SIRPa, Adenosine, STING & Others
Table of Contents
1) IDO & TDO Inhibitors

Epacadostat Studies
Indoximod Studies
Novel IDO Inhibitors
Novel TDO Inhibitors
Dual IDO & TDO Inhibitors

2) TGF-beta/R Inhibitors
3) CXCR4 Antagonists & CXCL12 Inhibitors
4) CSF-1R Antagonists & CSF-1R tk Inhibitors
5) CD47 SIRPa Pathway Inhibition
6) Adenosine Pathway

Adenosine A2 Receptor (A2AR) Antagonists
CD73 (AMPase) & CD39 (ATP/ADPase) Inhibitors and Adenosine Degradation

7) STING Receptor Stimulators
8) Other Inhibitors of Immunosuppressive Tumor Microenvironment
9) Corporate Tumor Microenvironment Modulator R&D Pipelines

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